PHT has partnered with Dr. Bruce Lipshutz of the University of California, Santa Barbara, to champion green chemistry processes. Through this collaboration, we’ve developed innovative technologies that streamline production of TPGS-750-M, the main intermediate used to reduce organic waste and lessen the environmental footprint for many common reactions and couplings.
Reactions
SnAR
NO2 Reduction
Aryl Amination
C-H Activation
Olefin Metathesis
Aromtic Borylation
Allylic Amination
Allylic Silation
Asymmetric CuH
Cu-catalyzed 1,4-Addition
Couplings
Peptide
Suzuki-Miyaura
Sonogashira
Negishi
Stille
Heck
Why Green Chemistry?
Organic solvents make up 70 percent of the organic waste created by chemical enterprises. As a leader among chemical manufacturers, it is our responsibility to advance the industry by diminishing this waste through the use of environmentally safe and sustainable manufacturing practices. In addition to the environmental benefits, Green Chemistry also reduces cost, creates a higher-purity product, and enables a higher yield for each reaction. Because we can recycle both the catalyst and solvent up to six times, Green Chemistry creates minimal waste, and gives our customers the most efficient, cost-effective high-purity product on the market.
Dr. Bruce Lipshutz
A leading professor in Chemistry and Biochemistry, Dr. Bruce Lipshutz has become a key partner in PHT’s continued commitment to sustainable chemical manufacturing. An award-winning researcher, Dr. Lipshutz is the 2017 recipient of the ACS H. C. Brown Award for Creative Research in Synthetic Methods for his work on replacing organic solvents with water -- a cornerstone of our manufacturing processes.
AUGUST 25, 2017
PHT is pleased to announce that our Green Chemistry collaborative partner, Dr. Bruce Lipshutz, and his colleague, Dr. Sachin Handa in the Department of Chemistry at the University of Louisville, have been selected by the ACS GCI Pharmaceutical Roundtable (ACS GCI PRT) to receive the ACS GCI PRT Peter J. Dunn Award for Green Chemistry and Engineering Impact in the Pharmaceutical Industry. Dr. Lipshutz and Dr. Handa were selected based on their innovative work in the development of newly engineered catalysts for sustainable surfactant chemistry in water.
The Peter J. Dunn award was established “to recognize outstanding industrial implementation of novel green chemistry and/or engineering in the pharmaceutical industry that demonstrate compelling environmental safety, cost, and/or efficiency improvements over current technologies.” Dr. Lipshutz and Dr. Handa’s work has clearly and powerfully demonstrated the use of nanomicelles and nanocatalysis to successfully carry out reactions of great relevance to the pharmaceutical industry. The use of water-based systems was coupled with a substantial reduction in the use of platinum group metals and results in significant sustainability advantages for the industry.
